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Tissue Clearing SmartLabel Pro System

The Ultimate Active Immunostaining Device

 

Rapid Immunostaining with Unparalleled Uniformity

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Fast, Easy, and Efficient

 

Fast: Label large, intact samples such as rodent organs an order of magnitude faster than with passive labeling (≤ 24 hours vs. weeks to months).

 

Easy: Turnkey operation – simply load the buffers and your sample & probes. Perform 2 distinct labeling experiments simultaneously thanks to SmartLabel’s dual chamber design.

 

Efficient: Uses a small amount of antibody (as little as ~3 µg) to label tissues the size of a whole mouse brain.

 

Reliable: Prevents tissue damage with Stochastic Electrotransport technology (Kim, PNAS, 2015). Our nanoporous membranes (patent-pending) eliminate tissue contamination and probe loss.


Complete and Uniform Labeling

 

Achieves unparalleled uniformity of signal intensity from surface to core using LifeCanvas’s advanced eFLASH (Yun, bioRxiv, 2019) protocol


Combines rapid, Stochastic Electrotransport-mediated (Kim, PNAS, 2015) infiltration of probes into tissue with the SWITCH technique (Murray, Cell, 2015) of controlling probe binding kinetics 

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Cost Savings by Avoiding Target Saturation

 

Prevents antibody depletion caused by excessive binding to superficial tissue sites and ensures the sample’s center is well-labeled.

 

Compatible with Many Cleared - Tissue Techniques

 

SHIELD (Park, Nature Biotechnology, 2018)

MAP (Ku, Nature Biotechnology, 2016)

SWITCH (Murray, Cell, 2015)

 

þ Features

Fast, Easy, and Efficient

Complete and Uniform Labeling

Cost Savings by Avoiding Target Saturation

Compatible with Many Cleared-Tissue Techniques


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